akorn promethazine codeine Things To Know Before You Buy
akorn promethazine codeine Things To Know Before You Buy
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Existence-Threatening Respiratory Depression Tell clients of the chance of life-threatening respiratory depression, like information and facts that the risk is greatest when commencing promethazine HCl and codeine phosphate oral Remedy and that it could manifest even at advised dosages [see Warnings and Safety measures (five.
The causal function of opioids inside the medical syndrome of hypogonadism is unidentified as the different health care, physical, Way of living, and psychological stressors that could affect gonadal hormone amounts have not been adequately controlled for in reports done to date [see Adverse Reactions (six)].
g., Those people with evidence of greater intracranial strain or Mind tumors), promethazine HCl and codeine phosphate oral Remedy may reduce respiratory push, and also the resultant CO2 retention can more raise intracranial force. Furthermore, opioids deliver adverse reactions which could obscure the scientific study course of clients with head accidents.
The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a bit soluble in Alcoholic beverages. The molecular pounds is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical structure.
Codeine Carcinogenicity scientific studies were being performed with codeine. Two-yr experiments in F344/N rats and B6C3F1 mice had been executed to evaluate the carcinogenic possible of codeine. No evidence of tumorigenicity was observed in male and woman rats at codeine dietary doses nearly 70 and 80 mg/kg/working day (roughly akin to 15 and 20 moments, the MRHD over a mg/m2 foundation, respectively).
Codeine has very low plasma protein binding with about 7 to twenty five% of codeine bound to plasma proteins. Codeine passes the blood brain barrier as well as the placental barrier. Little quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
Reduced hypertension. get more info A unexpected drop in blood pressure can materialize in a lot of people all through treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Remedy which may well lead to you to sense dizzy, faint, lightheaded, or weak, specially when you arise (orthostatic hypotension). Your chance of having this problem might be greater if you take Promethazine Hydrochloride and Codeine Phosphate Oral Alternative with selected other medicines that lower blood pressure.
Parenteral drug abuse is often connected with transmission of infectious illnesses for instance hepatitis and HIV.
Due to inconsistencies amongst the drug labels on DailyMed as well as capsule images supplied by RxImage, we not Exhibit the RxImage pill visuals connected to drug labels.
All information and facts introduced Here's not intended in its place for or choice to information from wellness care practitioners. Please speak to your health treatment Experienced about potential interactions or other possible complications before using any product. The Federal Food stuff, Drug, and Beauty Act need this observe.
Animal Info Reproductive toxicity scientific tests have not been performed with promethazine HCl and codeine phosphate oral Answer; having said that, scientific tests can be obtained with unique Lively substances.
Keep track of sufferers with a heritage of seizure Ailments for worsened seizure Manage all through promethazine HCl and codeine phosphate oral Resolution therapy.
“If everyone has any Akorn merchandise at your home, phone your pharmacy as quickly as possible and stick to up together with your prescriber,” Kann said.
Make certain that individuals have an oral dosing dispenser that measures the appropriate quantity in milliliters. Counsel clients regarding how to utilize an oral dosing dispenser and properly measure the oral suspension as prescribed.